Programme  Titles  Presenters  Topics 
Thursday, September 27, 2018
12:00-14:00  Registration
Regency Foyer
14:00-14:15  Opening Remarks
Regency BCD
14:15-15:15  Opening session
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14:15-14:25  Video welcome from Francis Collins
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14:25-15:15  [K01] Ned Sharpless NCI, USA | TBD
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15:15-16:15  Roundtable Discussion | The Cancer Genome Atlas: A model of cooperation
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16:15-16:45  Refreshment Break
Regency A
16:45-17:45  Meet the Editors Session
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17:45-19:00  Welcome Drinks Reception
Regency A
 
Friday, September 28, 2018
09:00-12:15  Session 1: Selected TCGA Project Vignettes
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09:00-09:30  [INV01] Daniel Brat | Northwestern University, USA | Diffuse Gliomas: A Journey from molecular discovery to new diagnoses to practice guidelines
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09:30-10:00  [INV02] Peter Laird, Van Andel Research Institute, USA | DNA methylation loss in late-replicating domains is linked to mitotic cell division
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10:00-10:30  [INV03] W. Marston Linehan | NCI, NIH, USA | TCGA comprehensive molecular characterization of renal cell carcinoma
Regency BCD
10.30-11:00  Refreshment Break
Regency A
11:00-11:30  [INV04] Matthew Meyerson, Dana-Farber Cancer Institute & Harvard Medical School, USA | Aneuploidy: Chromosome arm level alterations across cancer
Regency BCD
11:30-12:00  [INV05] Nuria Lopez-Bigas, IRB Barcelona, Spain | Whole-genome panorama of somatic mutations across cancers
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12:00-12:15  [ST01] NFE2L2 and the oxidative stress pathway - A pan cancer story of TCGA from signature to clinical trial | N. Hayes, University of Tennessee Health Science Center, USA
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12:15-12:25   Poster Teasers 1
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12:25-13:30  Lunch
Regency A
13:00-13:30  Workshop - Deciphering the biology that drives response to immunotherapy using multiplexed immunofluorescence – Phenoptics update | Linden Wyatt, PhD, Field Applications Scientist, Quantitative Pathology Solutions, PerkinElmer, USA
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13:30-15:00  Poster Session 1
Regency A
15:00-18:00  Session 2: Biological Discoveries through Multi-Omics Research
15:00-15:30  [INV06] Gordon Mills, Oregon Health and Science University, USA | Systems approach to rational combination therapy with PARP inhibitors
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15:30-16:00  [INV07] Cory Abate-Shen, Columbia University, USA | Modeling prostate cancer in genetically-engineered mice in the post-genomic era
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16:00-16:30  Refreshment Break
Regency A
16:30-17:00  [INV08] Hui Shen, Van Andel Research Institute, USA | Cellular and Molecular Origins of Testicular Germ Cell Tumors
Regency A
17:00-17:30  [INV09] Dvir Aran, University of California, San Francisco, USA | Digitally deconvolving the tumor microenvironment
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17:30-17:45  [ST02] Modeling genome-wide proteomic data refines epigenetic cancer driver nominations | O. Gevaert, Stanford University, USA
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17:45-18:00  [ST03] A systematic pan-cancer analysis of somatic variants reveals epigenetic drivers of intratumor heterogeneity | M.R. Matos, Faculdade de Medicina da Universidade de Lisboa, Portugal
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19:00-22:00  Meet the Speakers Dinner | Ticket holders only
 
Saturday, September 29, 2018
09:00-12:00  Session 3: Translational Insights from Multi-Omics Analyses
09:00-09:30  [INV10] Lillian Siu | University of Toronto, Canada | Multi-omic evaluation of biomarkers to predict response to immune checkpoint blockade: results from the Princess Margaret’s INSPIRE Study
Regency BCD
09:30-10:00  [INV11] Alice T. Shaw, Harvard Medical School, USA | Evolution of drug resistance: Translating discoveries to the clinic
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10:00-10:15  [ST04] Pan-cancer multi omics subgroup identification reveals association between patient survival and DNA damage response pathways | M. Büyüközkan, Institute of Computational Biology, Helmholtz-Zentrum München, Germany
Regency BCD
10:15-10:30  [ST05] Multi-omic analysis points to significant role of hedgehog signaling in hepatocellular carcinoma (LIHC) | D. Wheeler, Baylor College of Medicine, USA
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10:30-11:00  Refreshment Break
Regency A
11:00-11:30  [INV12] Rebecca Fitzgerald, University of Cambridge, UK | Clinical insights from multi-omic studies on esophageal cancer
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11:30-12:00  [INV13] Nicholas McGranahan, The Francis Crick Institute, UK | Lung cancer evolution and immune escape
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12:00-12:15  [ST06] Transcription elongation defects are common in cancers and confer resistance to anti-tumor immunity | K. Komurov, Cincinnati Children's Hospital Medical Cente
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12:15-12:25  Poster Teasers 2
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12:25-13:30  Lunch
Regency A
13:30-15:00  Poster Session 2
Regency A
15:00-18:00  Session 4: TCGA Pan Cancer Analyses
15:00-15:30  [INV17] Li Ding, Washington University St. Louis, USA | Perspective on oncogenic processes at the end of the beginning of cancer genomics
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15:30-16:00  [INV15] Vesteinn Thorsson, Institute for Systems Biology, USA | The immune landscape of cancer
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16:00-16:30  [INV16] Katherine Hoadley, University of North Carolina, USA | Pancancer integrated molecular classification
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16:30-17:00  [INV14] Nikolaus Schultz, Memorial Sloan Kettering Cancer Center, USA | Oncogenic signaling pathways in the cancer genome atlas
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17:00-17:30  [INV18] Carter Van Waes | NIDCD, NCI, USA | Genomic, pathway network, and immunologic features distinguishing squamous carcinomas
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17:30-17:45  Closing Remarks
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